ea0032p529 | Endocrine tumours and neoplasia | ECE2013
Ramundo Valeria
, Marciello Francesca
, Del Prete Michela
, Marotta Vincenzo
, Esposito Raffaella
, Chiara Carratu Anna
, de Luca di Roseto Chiara
, Colao Annamaria
, Faggiano Antongiulio
Introduction: Paragangliomas are neuroectodermal tumors that arise from adrenal medulla or extra-adrenal ganglia and are characterized by high vascularisation. A high rate of these tumours is genetically inherited. For malignant paragangliomas, chemo- and radio-therapy are potentially effective, but tumor response is of short duration and patient prognosis is quite poor. Sunitinib is a tyrosine-kinase inhibitor, targeting VEGFR1, -2, PDGFRα, -β, RET and c-Kit. Recent...